Paper ID: 60
An environmentally friendly one-pot synthesis method of 1,4 dihydropyridines through Hantzsch reaction
1 Laboratory of Phytochemistry and Pharmacology, Department of Chemistry, University of Mohamed Seddik Ben Yahia Jijel, Algeria
A simple, environmentally friendly and highly efficient method has been developed for the synthesis of 1,4 dihydropyridines (1,4-DHPs) compounds via one-pot Hantzsch reactions with good yields (70-90%). The framework of these compounds was constructed from an aromatic aldehyde, ethylaceto acetate and ammonium acetate, using kaolin in a solvent-free condition. The characterization of kaolin was carried out by X-ray diffraction (XRD), scanning electron microscopy (SEM) and X-ray photoelectron spectroscopy (XPS) technics. This ecologically friendly process has various benefits such as a green and cost-effective procedure, good yield, short reaction time and the ability to recover and reuse the heterogeneous catalyst many times.